Mad Barn Three Amigos Amino Acid Supplement

Size: 1 Kg
Sale price$40.00 CAD


Three Amigos is an essential amino acid supplement for horses providing lysine, methionine and threonine in a 5:3:2 ratio. This tri-amino blend contains three rate limiting amino acids that are commonly deficient in the equine diet. Three Amigos can help to support your horse’s hoof health, hair and coat quality, immune function, joints and muscles as well as athletic performance.

Mad Barn’s Three Amigos is an equine essential amino acid supplement providing an ideal blend of lysine, methionine and threonine to support your horse’s health and wellness.


Lysine, methionine and threonine are the three main limiting amino acids in the horse’s diet. Amino acids are molecules that serve as the building blocks of protein.

Optimal protein synthesis can only occur when all essential amino acids are sufficiently available. Essential aminos cannot be synthesized within the body and must be supplied by the diet.

If horses do not get adequate amounts of these three rate limiting amino acids in their diet, it can result in impaired protein synthesis and have negative consequences for immune function, growth, performance and overall health.

Our pure Three Amigos supplement can provide adequate levels of lysine, methionine and threonine to support optimal protein synthesis in all cells of the body. This will ensure that your horse has the structural proteins, enzymes, and immune components needed to promote complete wellbeing.

In horses, lysine is the first limiting amino acid meaning it is most likely to be low in the diet relative to physiological requirements. Protein synthesis rates will not be optimal until there is enough lysine available. Methionine and threonine are often considered the second and third limiting amino acids for horses.

Horses that have poor hoof growth, poor coat quality, or loss of muscle mass might have a protein deficiency in their diet. Low milk production in lactating mares and poor stamina are additional signs of deficiency.

Ensuring that your horse receives adequate levels of lysine, methionine, and threonine in their diet could correct amino acid imbalances, supporting normal function of all tissues in the body.


Lysine supplementation is recommended to support bone growth in growing horses as well as healthy joints in exercising and aging horses.

Lysine enhances calcium absorption from the gut, increasing the availability of this mineral for the formation of healthy bonesand supporting muscle and nerve function. [5]

Lysine is also essential for the formation of collagen, a structural protein that makes up skin and bones.

It is also required to synthesize carnitine, a vitamin-like nutrient that is important for the production of energy from fat tissue. Exercising horses may benefit from lysine to support energy metabolism and athletic performance. 


Threonine is an amino acid that is important for the digestive tract and nutrient absorption. Between 60-90% of dietary threonine is used by the tissues in the gut.

Threonine is required to produce mucin proteins which form a protective barrier in the intestines. When dietary threonine is low, it is prioritized for mucin production and may not be available in adequate amounts to support muscle growth or protein synthesis. [2]

Horses that are susceptible to gut problems may benefit from threonine supplementation. High-grain diets fed to performance horses can cause microbial imbalances that injure the intestinal lining and lead to ulcers.

Supplemental threonine might help these horses handle high-grain diets and improve nutrient absorption leading to improved overall health and stamina.

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